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Non-enzymatic antioxidants function through several mechanisms: Direct radical scavenging : Neutralizing free radicals by donating electrons or hydrogen atoms Metal chelation : Binding transition metals like iron and copper that catalyze free radical generation Quenching : Absorbing and dissipating the energy from reactive oxygen species Chain-breaking : Interrupting chain reactions of lipid peroxidation Regeneration : Recycling other antioxidants back to their active forms Unlike enzymatic antioxidants that catalyze multiple reactions without changing, non-enzymatic antioxidants become oxidized during their protective action and require regeneration

Vitamin C assists in this recycling process, which is why the two are often delivered together

Using ACEIs can counteract these negative effects and may reduce the risk of MI associated with high plasma levels of ang-II